Endocrine Abstracts

BackgroundHypoparathyroidism is a rare disorder characterized by hypocalcemia and hyperphosphatemia due to absent or inadequate parathyroid hormone secretion. Data on effective treatment strategies and predictors of long-term complications have only recently began to emerge. The epidemiological information regarding chronic hypoparathyroidism in Russia is strictly limited that prompted this research.AimsTo es...

BackgroundThe nonclassical complications of primary hyperparathyroidism (PHPT) can include metabolic syndrome associated with cardiovascular diseases. According to clinical studies, an increased incidence of diabetes mellitus, insulin resistance, obesity, dyslipidemia and other disorders are observed in patients with PHPT regardless of the severity of the disease. The aim of this study is to estimate metabolic parameters in patients with PHPT compared to...

The combination of thyroid and parathyroid carcinoma (PC) are extremely rare. We present a case with metastases of both tumors to the lymph nodes of the neck in a woman who received renal replacement therapy with long-term hemodialysis.Case reportIn 1984, when she was 24 years old, the patient began working at a nuclear power plant as a chemical water treatment operator. The total length of service was 25 years. In 2009 (at the age...

IntroductionVitamin D deficiency is considered as a major public health concern. Due to vitamin D’s crucial role in the intestinal calcium absorption, its deficiency may result in hypocalcemia and in a spectrum of associated clinical manifestations.AimTo assess the effect of 25(OH) vitamin D level (25(OH)D) on the frequency of hypocalcemia episodes and the daily profile of serum calcium and 24-h urinary ...

Background: Primary hyperparathyroidism (PHPT) during pregnancy is rare and often unrecognized. Most of these patients are asymptomatic or have nonspecific complaints but some of them сan present with classical symptoms of PHPT and even with severe complications of pregnancy as preeclampsia, miscarriage, preterm labor etc. The incidence of maternal complications is approximately 67%, poor fetal outcomes, including stillbirth and intrauterine growth retardation may reach 80...

Introduction: Parathyroid carcinoma (PC) is one of the rarest endocrine malignancies. Most PCs are sporadic, sometimes occurring in the framework of familial primary hyperparathyroidism (PHPT). PHPT due to PC is usually characterized by significantly increased PTH levels, severe hypercalcemia, larger tumor size and a higher incidence of disease complications. Clinical case: A 56-year-old male C. presented with an accidental formation at the posterior con...

Background: Metabolic syndrome may be the nonclassical feature of primary hyperparathyroidism (PHPT) because an increased incidence of various glucose and lipid disorders is often observed in patients with this disease. Earlier we showed PHPT patients had higher serum triglycerides and higher rate of insulin resistance compared to the control group. Dynamics of metabolic parameters after surgery is ambiguous.The aim: of this study was to compare metaboli...

Background: In some patients with primary hyperparathyroidism (PHPT), glomerular filtration rate (GFR) demonstrate decrease after parathyroidectomy (PTE). GFR may decrease immediately after surgery due to general anesthesia, but after a month not all patients restore kidney function; a decreased GFR is also observed after 1–2 years after surgery.Aim: To find the pre-surgical factors of GFR decrease after PTE.Methods: Patients ...

Objective: Normocalcemic primary hyperparathyroidism (PHPT) is a phenotype of PHPT characterized by normal serum calcium and persistently increased parathyroid hormone (PTH) after exclusion of secondary causes of PTH elevation.The aim: of this study was to investigate the capability of the short test with active metabolites of vitamin D for differential diagnosis between normocalcemic PHPT and secondary hyperparathyroidism (SHPT) for inpatient treatment....

Introduction: An atypical manifestation of disease combined with inconsistent results of examination, long history of multiple past health care services without effect requires to consider factitious disorders.Case report: A 46 year-old woman was suffering from episodes of severe hypokalemia (K+ 1.9 - 3.4 mmol/l (ref. 3.5-5.1 mmol/l) and hypertensive crises up to 240/145 mm Hg for 4 years. She stated that there was no clear provoking factor for these epi...